Characterization of SiC ceramics with complex porosity by capillary infiltration: Part B – Filling by molten silicon at 1500 °C

In Part A of this study, infiltrations experiments of porous SiC samples by hexadecane with pore-size distributions comprising small and large pores were realized. Two successive stages were identified during the filling of these samples corresponding to the infiltration of the two types of pores. The experimental data were successfully treated with a new analytical function. In Part B, it was found that this function can also be applied to the analysis of the mass gain during molten silicon infiltration at 1500 °C. Prior to silicon infiltration, it was found that the operating temperature induces a shift of the pore size distributions towards larger values. A dissolution-recrystallisation mechanism can also occur during the infiltration of silicon. During the first stage, liquid silicon fills rapidly larger pores than hexadecane. The kinetics are significantly larger with liquid silicon. Consequently, the durations for the complete filling are very short with molten silicon.     

NH2-MCM-41的改性及其pH响应性释药的研究

采用正硅酸乙酯（TEOS）和3-氨丙基三乙氧基硅烷（APTES）通过共缩聚法合成介孔二氧化硅（MCM-41）。首先对其氨基修饰，再通过有机合成接枝—R基团（—R：—CHO、—OH、—CH₃、—COOH），制备得到Me-Ph-NH-MCM-41、OHC-Ph-NH-MCM-41、HO-Ph-NH-MCM-41、HOOC-Ph-NH-MCM-41四种不同的药物载体。利用FT-IR、Zeta电位、XRD和SEM对其结构和形貌表征，结果表明NH₂-MCM-41改性成功。以罗丹明B（RhB）为模型进行载药性能测试，并考察了此释药系统在模拟不同pH的体液下的敏感释药行为，同时探究了不同—R基团对释药的影响。结果显示，四种载体在中性条件下几乎不发生药物释放，通过改变环境体系pH可以有效控制药物释放，其释药行为可以用Korsmeyer-Peppas动力学模型来描述。实验表明，释药量：RhB@HOOC-Ph-NH-MCM-41>RhB@OHC-Ph-NH-MCM-41>RhB@HO-Ph-NH-MCM-41>RhB@Me-Ph-NH-MCM-41，不同—R基团的药物载体的pH响应性不同，其中RhB@HOOC-Ph-NH-MCM-41释药量在pH=1.2时可达57.87%，在用于药物智能控释材料方面具有一定的应用潜力。     

Evaluation of behavior of the secondary columns in semi-supported steel shear walls

Semi-supported steel shear walls (SSSW), whose steel plate is connected to secondary columns rather than main columns of the frame, have been considered as an alternative steel shear walls to the traditional type. Many investigations have been made for proportionate designing of components of SSSW system. One of the important issues in this regard is the out of plane buckling of the secondary columns. In this paper, the plastic theory of structures is utilized to find out the axial force distribution, along the compressive column. Then, using energy method, for an assumed shear wall with specific geometry and material and a given shear force, the maximum overturning moment that makes the compressive secondary column buckles, can be determined. Repeating this method, for various shear forces, makes it possible to draw some interaction curves between overturning moments and shear forces. These curves can be used to analyze and design of semi-supported steel shear walls.     

空间经济学视角下城郊型开发区产城融合路径

首先从空间经济学视角分析了产城关系演变中的土地价值损失的形成及弥补过程,提出产城冲突下价值损失的构成、影响因素及扩大机制。随后,围绕价值损失的补偿方式指出了产城融合的三条路径,并对现实中各类路径的应用给出了宏观及微观解释——我国城镇化和工业化发展的阶段性变化、不同类型产业的产出效率及其就业人群需求差异是路径选择的决定性因素。最后,本文指出了进一步的研究方向,即通过合理的制度安排,减少产城融合过程中不同主体之间利益再分配所需的交易成本。     

A smooth curve evolution approach to the feedrate planning on five-axis toolpath with geometric and kinematic constraints

Feedrate planning with geometric and kinematic constraints is crucial for sculptured surface machining. Due to the non-linear relationship between the Cartesian space and the joint space, the feedrate planning method for a given five-axis toolpath is very limited compared with that in three-axis machining. To achieve the exact control of the chord error and the kinematic characteristics of cutter and machine tool, this paper presents a new feedrate planning method for five-axis parametric path using a smooth curve evolution strategy. The constraints in feedrate planning are first classified as two types of neighbor-independent (NI) constraints and neighbor-dependent (ND) constraints. Then for constraint violated region, the detailed formulas of determining the update feedrates of violated sampling points are given using a decoupled manner. As a result, NI and ND constraints are satisfied respectively with one step and multi-step smooth curve evolution technique, which can smoothly deform the target feedrate profile to the desired update positions. Simulations and experiments are performed on the given tool path to validate the effectiveness of the proposed feed planning method. The results show that the proposed method is robust and effective in the exact control of constraints in the feedrate planning on complex five-axis toolpath.     

测井曲线标准化方法研究

由于长岭凹陷区经过近60年的勘探开发,再加上井场井眼条件的差异、测井系列、仪器刻度、测量时间及操作者不同等因素,使得各测井曲线存在系统误差。因此在开展储层参数研究和有效厚度划分时,为消除这些非地层因素对原始资料的影响,有必要对测井曲线进行标准化,以保证解释结果的合理性与可靠性。测井曲线标准化方法可以分为定性和定量两种类型。其中定性方法主要包括直方图法标准化校正、均值法标准化校正和重叠图法标准化校正;定量方法则为趋势面分析校正法。本论文利用Matlab软件,采用趋势面方法对研究区域内的井进行测井曲线标准化。结果表明经过趋势面法标准化校正能够消除不利因素,准确的提取出测井曲线中的各种有用地质信息。     

Predictions of frame compliance and apex morphology in sharp nanoindentations

If all components in a nanoindentation system are well calibrated and a reference material has unique hardness, H and reduced modulus, E_r independent of the indentation depths, the load, L and the penetration depth, h in the indentation loading curve of the reference material can be correlated by L=Kh². Here the constant K is expressed by H, E_r and indenter geometry constants. By using H and E_r of a fused silica and the Berkovich geometry, an analytical expression for the indentation loading curve could be derived. To compare with this analytical loading curve, experimental indentation data were measured with two commercial nanoindenters. The experimental loading curves shifted leftward or rightward from the analytical loading curve and this depth deviation was attributed to improper calibration of the nanoindenters. Quantitative calibrations of frame compliance and indenter bluntness were tried for the raw nanoindentation data and this resulted in consistent nanoindentation data regardless of the used nanoindenters.     

Damage accumulation modeling under uniaxial low cycle fatigue at elevated temperatures

The paper presents a fatigue damage accumulation model, which allows us to predict fatigue life under low cycle uniaxial loadings at elevated temperatures. The structure of the model has been based on the stress–strain curves obtained during the experimental study. The model has been verified experimentally by applying experimental studies carried out on ENAW-2024T3 aluminum alloy and 2Cr–2WVTa steel. Moreover, a comparison between the results of fatigue life prediction using the proposed damage accumulation model was done with the results obtained on the basis of various generally applied models, based on the Manson–Coffin dependency. Furthermore this paper presents the results of experimental studies carried out on the aluminum alloy ENAW 2024 T3 under uniaxial low cycle fatigue loadings in the conditions of elevated temperatures. In the course of the study, material constants and the parameters of the stress–strain curve in the range of low cycle fatigue for four levels of temperatures (20, 100, 200 and 300 °C) were set.     

Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates

Biocatalysis offers an alternative approach to conventional chemical processes for the production of single-isomer chiral drugs. Lipases are one of the most used enzymes in the synthesis of enantiomerically pure intermediates. The use of this type of enzyme is mainly due to the characteristics of their regio-, chemo- and enantioselectivity in the resolution process of racemates, without the use of cofactors. Moreover, this class of enzymes has generally excellent stability in the presence of organic solvents, facilitating the solubility of the organic substrate to be modified. Further improvements and new applications have been achieved in the syntheses of biologically active compounds catalyzed by lipases. This review critically reports and discusses examples from recent literature (2007 to mid-2015), concerning the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and their intermediates in which the key step involves the action of a lipase.